Environmental Pollution by Benzo (a) pyrene and Its Emission Sources
نویسندگان
چکیده
منابع مشابه
Inhibition of Benzo(a)pyrene and Benzo(a)pyrene 7,8-Dihydrodiol Metabolism by Benzo(a)pyrene Quiñones1
Benzo(a)pyrene 1,6-, 3,6-, and 6,1 2-quinones were found to be noncompetitive inhibitors of mixed-function oxidation of benzo(a)pyrene (BP) and frans-7,8-dihydro-7,8-dihydroxybenzo(a)pyrene (BP 7,8-dihydrodiol). BP 6,1 2-quinone was the most potent inhibitor of both BP and BP-7,8-dihydrodiol oxi dation followed by BP 1,6-quinone and BP 3,6-quinone. The K, for inhibition of BP mixed-function oxi...
متن کاملInhibition of benzo(a)pyrene and benzo(a)pyrene 7,8-dihydrodiol metabolism by benzo(a)pyrene quinones.
Benzo(a)pyrene 1,6-, 3,6-, and 6,1 2-quinones were found to be noncompetitive inhibitors of mixed-function oxidation of benzo(a)pyrene (BP) and frans-7,8-dihydro-7,8-dihydroxybenzo(a)pyrene (BP 7,8-dihydrodiol). BP 6,1 2-quinone was the most potent inhibitor of both BP and BP-7,8-dihydrodiol oxi dation followed by BP 1,6-quinone and BP 3,6-quinone. The K, for inhibition of BP mixed-function oxi...
متن کاملDifferential metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1 variants.
Cytochrome P450 1A1 (CYP1A1) plays a key role in the metabolism of carcinogens, such as benzo[a]pyrene (B[a]P) and metabolites to ultimate carcinogens. Three human allelic variants, namely wild-type (CYP1A1.1), CYP1A1.2 (I462V) and CYP1A1.4 (T461N), were coexpressed by coinfection of baculovirus-infected insect cells with human NADPH-P450 reductase. These recombinant enzymes (in microsomal memb...
متن کاملBenzo[a]pyrene prioritization
This is a compilation of abstracts of articles identified during the preliminary toxicological evaluation of evidence on the developmental and reproductive toxicity of benzo[a]pyrene (BaP, CAS# 50-32-8). BaP is a polycyclic aromatic hydrocarbon and a component of air pollution. Polycyclic aromatic hydrocarbons are formed as a result of incomplete combustion of organic materials and are ubiquito...
متن کاملBenzo(a)pyrene Phenol Production by Perfused Rat Liver and Its Inhibition by Ethanol1
A rapid and inexpensive method has been developed to estimate rates of benzo(a)pyrene phenol production by per fused rat liver. This method is based on the measurement of benzo(a)pyrene phenols utilizing a simple fluorometric proce dure. Within 2 to 3 min after infusion of benzo(a)pyrene bound to serum albumin, phenols are excreted into the perfusate, primarily as glucuronide and sulfate conjug...
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ژورنال
عنوان ژورنال: Journal of Japan Oil Chemists' Society
سال: 1976
ISSN: 1884-2003
DOI: 10.5650/jos1956.25.711